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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid-β aggregation, tau hyperphosphorylation, and neuroinflammation. MicroRNAs (miRNAs) play a critical regulatory role in key mechanisms of AD pathogenesis and show altered expression in AD brain and blood. This chapter explores the multifaceted roles of miRNAs in AD, with a focus on their involvement in neuroinflammation, and highlights their potential as diagnostic biomarkers and therapeutic targets.

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Decoding the Involvement of miRNAs in Alzheimer’s Disease: Focus on Neuroinflammation

  • 章节

  • 发表日期：

    2025年

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  • Simran Yadav,
  • Urszula Wojda

摘要

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by amyloid-β aggregation, tau hyperphosphorylation, and neuroinflammation. MicroRNAs (miRNAs) play a critical regulatory role in key mechanisms of AD pathogenesis and show altered expression in AD brain and blood. This chapter explores the multifaceted roles of miRNAs in AD, with a focus on their involvement in neuroinflammation, and highlights their potential as diagnostic biomarkers and therapeutic targets.