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Aging is the primary risk factor for numerous chronic diseases, driven in part by cellular senescence and associated epigenetic changes. Next-generation sequencing (NGS) technologies have transformed aging research by enabling high-resolution analysis of genetic, transcriptomic, and chromatin landscapes. Single-cell and spatial NGS approaches reveal the heterogeneity of aging tissues and uncover dynamic molecular interactions, such as senescence-associated pathways and chromatin remodeling processes. These advancements provide critical insights into the mechanisms of aging and open new avenues for therapeutic interventions targeting age-related diseases.

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Deciphering (Epigenetic) Mechanisms Behind Aging and Senescence Using Next-Generation Sequencing Technologies

  • 章节

  • 发表日期：

    2025年

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  • Dominik Saul,
  • Onur Mert Batmaz,
  • Patricia Raude,
  • Vera Leidig,
  • Xiaodong Wang,
  • Robyn Laura Kosinsky

摘要

Aging is the primary risk factor for numerous chronic diseases, driven in part by cellular senescence and associated epigenetic changes. Next-generation sequencing (NGS) technologies have transformed aging research by enabling high-resolution analysis of genetic, transcriptomic, and chromatin landscapes. Single-cell and spatial NGS approaches reveal the heterogeneity of aging tissues and uncover dynamic molecular interactions, such as senescence-associated pathways and chromatin remodeling processes. These advancements provide critical insights into the mechanisms of aging and open new avenues for therapeutic interventions targeting age-related diseases.