In tissue engineering approaches, the use of tissue scaffolds that mimic the properties of tissue-specific extracellular matrices by providing structural support and facilitating cellular processes has gained importance for producing three-dimensional (3D) functional tissues and organs to repair or replace damaged tissues. For cell adhesion, proliferation, migration, differentiation, and tissue formation, cells must receive the necessary biochemical and/or mechanical signals from their environment. Therefore, tissue scaffolds that can provide a suitable 3D environment and the necessary water content in terms of biochemical, biomechanical, and topographic aspects are needed. In the formation of tissue scaffolds, the synthetic or natural biomaterials that have porosity, wettability, biodegradability, mechanical, and surface properties suitable for mimicking natural extracellular matrix are preferred. In this way, the interactions between cells and biomaterials enable the tissue regeneration process to be directed correctly. Up to today, no hydrogel system has been developed that mimic the native tissue closely enough. However, advances in tissue engineering and biomaterials will surely enable the development of novel hydrogel approaches that mimic the tissue structurally, mechanically, and also in terms of chemical composition and dynamic properties.