Hydrogels are made from hydrophilic homopolymers or copolymers. Due to their high water retention capacity, they possess a soft and flexible tissue-like quality, resulting in low friction with surrounding tissues. They also exhibit low adhesion properties with mucosal surfaces and tissues, allowing them to be easily removed from a wound when applied. Because of their water absorption capability, they are used for the excretion of excessive amounts of body fluids. In the preparation of hydrogels, synthetic polymers are preferred in some cases due to the difficulties associated with the chemical modification of natural polymers and the potential of natural polymers for inducing an immunological response in the human system. Synthetic hydrogels are used in various applications, including tissue engineering scaffolds, drug delivery systems, wound dressings, lubricants, contact lenses, etc. Synthetic hydrogels can be designed and synthesized to demonstrate a diverse range of features and perform specific functions based on their chemical structure, synthesis methods, and types of crosslinking. In this chapter synthesis, characteristics, and biomedical uses of synthetic hydrogels are covered.