In order to obtain real-time multi-physiological parameters of sports athletes, improve sports performance, prevent sports injuries, and optimize training plans, research on real-time monitoring of multi-physiological parameters of sports athletes based on wearable sensors was carried out. First, the selection of wearable sensors was carried out, and their configuration parameters were designed. Second, design the distribution of wearable sensor device nodes to ensure monitoring effectiveness and application performance. On this basis, physiological parameter feature values of athletes are extracted to better understand their physical condition and performance level. Finally, wear sensors to monitor multiple physiological parameters of sports athletes in real time. The evaluation outcomes indicate that the technique exhibits commendable stability and real-time capabilities after implementation, effectively fulfilling the requirements for extended, uninterrupted, and precise surveillance.