This chapter centers two initiatives that formalized the introduction of Western medicine in British India: the founding of the Calcutta Medical College (CMC) in 1835 and the first dissection of a human cadaver (1836). Marking the colonial instauration of the anatomo-clinic, these foundational events became, along with the discipline of English literature, part of the project of epistemic overhaul that produced new colonial subjects and worlds. The entanglement of medicine and literature is explored through the apotheosis of the figure of the Hindu anatomist in painting and oratory. Drawing on the epic figures and locutions of English poetry, colonial pedagogues’ orations sought to inspire caste-bound natives, primed by their English studies, to take to the study of Western medicine, even if, after 1836, that meant touching the dead body. Concerned to ensure that cadaveric dissection as a teaching technique would not be shunned in “superstitious” India, colonial educators tilted at caste-prejudice, carefully bracketing the dark early nineteenth-century culture of dissection in early nineteenth-century Britain where too dissection continued to be stigmatized. Cross-referencing medical developments in colony and metropolis, the chapter spotlights the contrast between the low tone of the metropolitan culture of anatomy, involving murder and graverobbing, with the elevated rhetoric around the anatomist in India. What had begun in 1835 as a practical attempt to train up Indians as subordinate medics in the colonial army gradually swelled into an ambitious project swathed in grandiloquent rhetoric that urged Indian elites to become “men of science,” “new Adams” liberated from the dread of death, ready to extract knowledge from dead matter, and make the age their own. The chapter’s transimperial framing of colonial anatomy also makes visible other connective tissue binding different cultural, scientific, and commercial enterprises that made up empire’s necrosphere in the early nineteenth century. The epistemological and material continuities between medical-curricular innovations at the CMC and large-scale enterprise related to coal mining are key insights yielded by this chapter’s innovative ecological method.