Metallic implants are engineered biomaterials that are widely used to replace or repair damaged or diseased biological tissues in applications such as dental implants, orthopaedic fixations, cardiovascular stents, and joint replacements. Despite their advantages, the prolonged use of metallic biomaterials can lead to challenges such as infection, mechanical instability, inflammation, poor osseointegration, and complications that may result in necrosis. This chapter explores advanced solutions, including novel alloys and composites, to address these issues. Advanced additive manufacturing techniques, such as selective laser melting (SLM) laser powder bed fusion (LPBF), electron beam powder bed fusion (EBPBF), directed energy deposition (DED), and binder jetting (BJ) have been evaluated for their influence on material properties. Additionally, this chapter discusses in-depth insights into additive manufacturing for metallic implants in biomedical applications. Key tribocorrosion and biocompatibility factors such as corrosion and wear resistance, osseointegration, and antimicrobial performance were critically assessed. The chapter also highlights the potential limitations of smart implants (sensors and drug delivery systems) and shape-memory alloys for mechanical adaptability. Biomechanical considerations such as load-bearing capacity, fatigue resistance, and efforts to reduce the effects of stress shielding are discussed in the context of implant longevity. Additionally, personalized medical approaches are examined through patient-specific designs and customized surface treatments. The implant-tissue interface was analyzed by investigating cell-material interactions, tissue integration mechanisms, and inflammatory response regulation. This comprehensive overview provides valuable insights into the recent advancements and future directions for the development of metallic biomaterials for biomedical applications.