Titanium alloys have exceptional mechanical properties and bio-compatibility, making them vital for usage in biomedical applications, particularly in implants and prosthetics. The wear mechanisms and tribological behaviour of titanium alloys are examined in this section, with a focus on the materials performance in the dynamic environment of the human body. The unique challenges posed by the biological environment, such as the presence of physiological fluids, varying pH values, and complex loading conditions, necessitate a comprehensive understanding of the wear processes that these alloys undergo. By the developments in 3D printing technology, titanium implants and bio-organs may now be expertly constructed, offering unprecedented degrees of customization and compatibility. Still, there are new tribological problems associated with these advancements. This study investigates the effects of alloy compositions, surface changes, and 3D printing settings on the durability and wear resistance of titanium implants. The chapter offers insights on maximization the performance of 3D-printed titanium components in biomedical settings by looking at both actual results and theoretical models. Enhancing the robustness and usefulness of titanium-based biomedical devices is essential for improving patient outcomes by addressing tribological issues through creative material design and processing techniques.