Education 5.0 is a paradigm that seeks to humanize work environments by integrating technology into the processes of the educational institution. This paper aims to identify the implications that the process of digital transformation in a higher education institution has had on the organizational culture, for which a qualitative study was conducted with the participation of those responsible for the different areas of digital transformation to answer the question: What implications has the process of digital transformation in a higher education institution had on the organizational culture? It is concluded that the human factor strengthened by a robust organizational culture promotes continuous openness to technological developments and their implications in the different processes of the university task.