To reduce costs, energy consumption, and safety management difficulties, increasingly tall buildings are adopting connected structures. Due to the complex dynamic characteristics and surrounding environment, wind-resistance design of multi-tower structure has become a key focus of structural design. Four towers linked together by a 300 m long conservatory sitting atop is as the case study. Using the synchronize multi-high frequency force balance (MHFFB) testing technology, the wind-induced response and equivalent static wind load of a complex multi-tower structure with different structure systems were obtained, and the unique advantages of high-frequency force balance technology were utilized in the scheme stage. The wind force time-history was obtained from force balance data, and Ls-Dyna was used to analyze the performance of the isolation bearings between the tower and the bridge under wind load in the time domain. Attention should be paid to the phenomenon that the bridge under friction isolation bearings cannot automatically return to its initial position under wind load. The method combined MHFFB test technology and time-history domain analysis was recommended for the wind-resistant design of multi-towers in the scheme design or preliminary design stage.