Rational use of admixtures is an effective means to avoid cracking of mass concrete. The effects of temperature rising inhibitor, composite expansion agent, PVA powder and PP fiber content on the crack resistance of concrete were studied by response surface method. The relationship model between the shrinkage rate and compressive strength of concrete and the content of four admixtures is established, and the optimal mix ratio of crack-resistant concrete was obtained. The results show that the shrinkage rate of concrete decreases first and then increases with the increase of temperature rising inhibitor and PVA powder content. With the increase of composite expansion agent and PP fiber content, the shrinkage rate of concrete decreases gradually. The compressive strength of concrete increases first and then decreases with the increase of temperature rising inhibitor, composite expansion agent and PP fiber content. With the increase of PVA powder content, the compressive strength of concrete decreases gradually.