In order to analyze the influence of the variation of liner concrete parameters on the dynamic characteristics and seismic response of a corrugated steel web (CSW) continuous rigid bridge, this paper takes a corrugated steel web continuous rigid bridge as the background, and adopts numerical simulation to analyze the influence of the variation of the parameters of liner concrete, such as thickness, length, and arrangement position, on the self-oscillation frequency and vibration mode of the bridge. At the same time, the response spectrum and time course analysis are used to analyze the effect of the presence or absence of lined concrete on the seismic response of the bridge. The results show that: the setting of concrete lining has a greater influence on the fundamental frequency of the structure; the torsional stiffness tends to increase with the increase of the thickness of concrete lining and the length of the longitudinal direction; the results of the response spectrum analysis show that the maximum displacements and stresses of the bridge in the transverse direction are reduced after the setting of concrete lining; and the time-course analysis concludes that the displacements and stresses of the critical cross sections are reduced after the setting of concrete lining.