This chapter analyzes how Chile became a regional reference in transparency and corruption control through institutional design and policy innovation. Building on comparative and institutional approaches, the authors trace the evolution of Chile’s anti-corruption framework from the transition to democracy to the consolidation of public integrity systems. The study highlights key reforms—meritocratic civil service, transparency law, criminal liability for corporations, lobbying regulation, and digital procurement systems—that transformed governance structures and strengthened accountability. By aligning national reforms with global standards from the OECD and the UN Convention against Corruption, Chile developed a model emphasizing integrity, collaboration, and technological transparency. The section concludes with lessons for Latin America on institutional capacity, public trust, and the design of adaptive, integrity-based governance systems.