This paper investigates the changes in lift and drag coefficients, as well as the lift-to-drag ratio, for two airfoils designed for small wind turbines operating at low Reynolds numbers. The results include 2D simulations performed using the commercial software ANSYS Fluent 2019, along with wind tunnel tests conducted using the AF6116 setup. The two selected airfoils, EPU-E387 and EPU-S1010, are newly developed and have not yet been studied for their aerodynamic performance. The research method involves varying the angle of attack (AoA) to determine the optimal angle and identify which airfoil offers greater stability. The Reynolds numbers applied in the 2D simulations are 50,000, 60,000, 90,000, and 120,000. The simulation results indicate that the EPU-E387 airfoil achieves the highest lift-to-drag coefficient at the optimal angle of attack, which is 13.13% higher than that of the EPU-S1010 airfoil at a Reynolds number of 120,000. Additionally, the EPU-E387 airfoil demonstrates greater stability compared to the EPU-S1010 at higher angles of attack.