Janice Fanning Madden is a pioneer in regional science research in her analysis of spatial labor markets and the economics of discrimination. She is also a pioneer in gender access, being the first female faculty member to achieve tenure in the Department of Regional Science at the University of Pennsylvania. Her career expanded on the areas she studied, as Janice had enormous influence on the practical operation of her university and on many Ph.D. graduate students. Moreover, what other academic can claim awards from both the Regional Science Association International and the National Football league? In this chapter Janet Kohlhase traces the many research accomplishments of Janice Madden as well as her extraordinary service to all areas she touched at Penn, to regional science, and to other academic communities. Madden’s work focuses on differentials over space including gender, race, employment status, family status and income. Three of her seminal papers used the tenets of regional science to make major contributions to the understanding of wage and other disparities among groups and across space. She was the first to untangle the reasons why women work closer to home than do men, spawning a large subsequent literature. The influence of her work has been widespread: in addition to regional science, she has impacted research in labor economics, urban economics, urban studies and even sports economics.