Cardiotoxicity encompasses a plethora of different conditions that damage the heart muscle and are associated with diminished function of the heart. Common examples of diseases that this encompasses are arrhythmias, coronary artery disease (CAD), heart failure, and myocardial infarction. Cardiotoxicities are commonly caused by cancer treatments such as chemotherapy, radiation therapy, anthracyclines, etc. This is why it is very important to monitor cancer patients and cancer survivors and promote preventative/maintenance strategies to prevent the occurrence/reoccurrence of cardiotoxicity. A prominent therapy utilized is increasing physical activity. Exercise can provide an array of benefits that function to improve cardiovascular health and mitigate the effects of cardiotoxicity. The benefits of exercise can spread to other comorbidities of cancer patients and help improve the overall condition by helping alleviate those symptoms as well. These include comorbidities such as tobacco use side effects, psychosocial effects, lipid management, and diabetes management. Increased physical activity has been proven to show improvements in these comorbidities by increasing quality of life, preventing malignancy occurrence/reoccurrence, and improving a patient’s overall well-being. Multiple facets of exercise have been shown to improve patient outcomes, but emphasis has been placed on personally tailored exercise regimens and resistance training which have shown better results. An issue that is hard to overcome is the physical limitations that patients experience when attempting to increase physical activity, but through personally tailored exercise regiments, those limitations can be considered and a proper routine that can be beneficial for the patient can be created without inducing extra psychosocial strain. Furthermore, if patients are not able to obtain this type of treatment, any increase in physical activity has been shown to improve patient outcomes. However, due to the lack of structure, patients are more likely to forgo exercise that can provide valuable health benefits. Due to these limitations, physicians do not emphasize exercise and its benefits. By prioritizing the benefits of exercise, physicians can push patients to actively engage in improving their own well-being, cardiovascular health/overall health, and reduce treatment for secondary comorbidities.