Since the beginning of the twenty-first century, endoscopic treatments for gastroesophageal reflux disease (GERD) have emerged as viable alternatives to traditional medical and surgical therapies. This approach is indicated for patients with GERD who are refractory to medical therapy, those who are not candidates for surgery, or those preferring a less invasive option. In fact, some of these minimally invasive procedures have demonstrated good efficacy along with an excellent safety profile. This chapter delves into the various endoscopic techniques developed, their mechanisms, clinical outcomes, and future directions. Key procedures discussed include injection of bulking agents, radiofrequency energy treatment, transoral incisionless fundoplication, endoscopic full thickness plication, antireflux mucosectomy and mucosal ablation. Clinical outcomes and complication rates are reviewed, supported by data from most recent studies and trials. By providing a detailed examination of these minimally invasive procedures, this chapter aims to inform clinicians about the potential benefits and limitations of endoscopic treatments for GERD, ultimately enhancing patient care and expanding therapeutic options.