This study aims to inspect the influence of macroeconomic elements (Inflation-INR, GDP, and unemployment rate-UR), and microeconomic factor (operational cost OPC), on the financial performance of 33 industrial companies listed at Amman Stock Exchange (ASE) from 2012 to 2021. Employing return on assets (ROA) and cash flow per share (CFS) as dependent variables, the research uses multiple regression analysis. The findings indicate that (UR) has a significant negative impact on (ROA). However, OPC has a significant positive impact on both return on assets and cash flow from operations. Based on that, the study also stresses the necessity of industrial organizations adopting strategic plans in order to foresee and mitigate the effects of fluctuations in the macroeconomic environment. It also recommends the importance of monitoring the impact of macroeconomic data, in order to mitigate its potential negative impact, by investing in new technologies that reduces the operational cost more efficiently.