This chapter deals with obstacles in the implementation of feedback-informed treatment (FIT) into clinical practice. Based on experiences with the Trier Treatment Navigator (TTN) in the outpatient clinic of the University of Trier, obstacles that we have been facing, solutions that we have developed, and opportunities for a successful implementation are discussed. At the beginning, the chapter covers ideas on assessments, validity of predictions and recommendations, and how to present the measurement-based feedback to therapists. After a brief consideration of the patient’s role, the training of therapists will be addressed. The training should comprise a rationale for the application of FIT, a practical perspective on how to use the FIT system, relevant therapeutic content, and support in handling critical events, such as symptom worsening. Involving therapists into the development is a further favoring aspect of a successful implementation. In the end, the extension of the reach and more global national changes are raised that could support implementation. This includes the expansion to colleagues in private practice, research-practice networks, and also international coordination, for example, within Europe. Looking to the future, the introduction of a national quality assurance system that defines FIT as a standard procedure is being considered.