In this chapter, we continue our discussion by exploring additional intra-operative factors and post-operative considerations. To recap, Fig. 21.1 illustrates the intra-operative factors we have covered thus far: achieving apical patency and preserving peri-cervical dentine. In this part, we will further discuss intra-operative factors, such as the length, density, and taper related to obturation, as well as managing intra-operative flare-ups. Additionally, we will address post-operative considerations that influence the overall success and longevity of endodontic treatments. Our aim is to provide comprehensive prognostic guides for clinicians, ensuring well-informed decision-making throughout the treatment process.