The majority of menstrual taboos are informed by religious teachings on menstruation, which are based on a skewed perception of menstruation—as ‘unclean’, ‘impure’, and ‘polluted’. These taboos are also rooted in misogynistic and patriarchal norms that perpetuate harmful stereotypes against women and girls in Africa, thereby impeding the dignity and agency of women and girls. This chapter embarks on a broader examination of the impact of menstrual taboos on the rights of women and girls in Africa. It adopts an African feminist lens and a rights-based approach to understand the consequences of religious stigmatisation of menstruation on women and girls in Africa. The chapter finds that menstrual taboos negatively impact the right to non-discrimination, health, information, and dignity of women and girls in Africa. It recommends that concerted efforts by governments and relevant stakeholders must be taken to address menstrual taboos to protect women and girls in Africa.