With rapid industrialization, the agro-based rubber business provides raw materials for numerous industries. Wastewater pollution from rubber processing industries has been on the increase in the countries of Africa and Asia because of the growing number of mature rubber trees. During the various production processes, a lot of chemicals and water are used, which leads to the generation of large amounts of highly polluted wastewater. This wastewater is characterized by high toxicity, strong odour and colour, low pH, high suspended solids, high temperature, and high chemical and biological oxygen demand (i.e. COD and BOD). These undesirable characteristics make it imperative to treat the highly polluted raw rubber processing wastewater before it is discharged into water bodies. This chapter is a discourse on the importance of efficient management of wastewater from natural rubber processing industries. It highlights the physicochemical characteristics of the wastewater and its impact on the environment. Special emphasis is laid on the conventional and non-conventional technologies that are being used in the management of wastewater from the natural rubber industry.