This chapter is devoted to presenting the empirical findings and proposing a framework for applying strategic design in the third sector. It encompasses an analysis of best practices and first-hand experiences derived from research projects, emphasising the methodologies and outcomes associated with the application of strategic design. These results include the development of product and service offerings, paradigm shifts in co-creation and production processes, initiatives of new organisational structures and culture, and new systems. The chapter concludes with the introduction of the concept of organisational encounter that creates the conditions for connecting internal and external actors of TSOs for co-creation. A process model is also presented to serve design researchers and practitioners with a strategic design mindset, process, methods, and tools to develop innovative solutions with social responsibility.