The characteristics of the third sector offer a new context to explore the potential application of strategic design and design thinking. Based on the understanding of strategic design and its contribution to business innovation, organisational changes, and systemic transition in the social context, this chapter starts the investigation on how strategic design theories and practices could be aligned with the objectives and strategies of the Third Sector Organisations to cultivate the innovation, and on the other hand, how Third Sector Organisations provide opportunities and spaces for further developing knowledge on the strategic design area.