The growing number of outmoded electronic gadgets has made e-waste a major environmental and economic concern. Electronic waste contains priceless precious metals including gold, silver, and platinum, as well as dangerous compounds that require proper disposal and environmentally friendly recycling solutions. Biotechnological approaches using microbes and enzymes offer a cost-effective alternative to classic extraction methods. Microorganisms like Acidithiobacillus ferrooxidans, Leptospirillum ferrooxidans, and Pseudomonas can bleach metals via acidification, complexation, and redox processes. Enzymatic methods, such as hydrolases and oxidoreductases, can improve metal recovery while minimizing environmental impact. This study emphasizes the efficiency, scalability, and low ecological footprint of biotechnological methods for recovering precious minerals from e-waste. Integrating these techniques into e-waste recycling frameworks could significantly contribute to sustainable resource recovery and pollution reduction.