The decision to offer resection, transplant, or other therapy to patients with compensated cirrhosis and portal hypertension is very complex. This chapter reviews the evidence behind the treatment modalities and identifies cases where resection may be useful and where it might be dangerous for our patients. We find that in select patients, resection may be feasible and safe depending on patient factors and the size of resection. However, studies have demonstrated grave 3- and 5-year survival rates. Patients with portal hypertension greater than 10 mmHg should generally be excluded from resection.