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The recommendation for semi-annual HCC screening is based on tumor doubling time. This frequency is associated with earlier diagnosis and improved survival compared to annual surveillance, after adjusting for lead-time bias. The French multicenter randomized HCC 2000 trial did not demonstrate the benefit of 3-month surveillance in terms of early detection and survival. Personalized approaches refining surveillance timeframe will require accurate prediction of both incidence and tumor doubling time (TDT) in patients with cirrhosis to design adequate randomized trials. To date, the recommended surveillance interval for HCC is 6 months for all eligible patients.

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Should Surveillance Be Performed Every 6 Months in All Patients with Cirrhosis?

  • 章节

  • 发表日期：

    2025年

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  • Pierre Nahon,
  • Olivier Seror

摘要

The recommendation for semi-annual HCC screening is based on tumor doubling time. This frequency is associated with earlier diagnosis and improved survival compared to annual surveillance, after adjusting for lead-time bias. The French multicenter randomized HCC 2000 trial did not demonstrate the benefit of 3-month surveillance in terms of early detection and survival. Personalized approaches refining surveillance timeframe will require accurate prediction of both incidence and tumor doubling time (TDT) in patients with cirrhosis to design adequate randomized trials. To date, the recommended surveillance interval for HCC is 6 months for all eligible patients.