In biomechanical study, the intricate nature of human skin presents substantial untapped potential due to its biological structure, particularly in simulation and computational biomechanics. Previous studies have produced approximate results using second-order Ogden material for the human body. However, there is still a lack of computational evidence to demonstrate that the Ogden model is consistently suitable to replace human or artificial skin. Moreover, the material’s mechanical characteristics remain challenging in accurately determining the material parameters used in simulation studies. This paper employs the Ogden formulation as a hyperelastic material model for simulating human skin. Utilizing reference data from prior studies, the non-linear finite element method (FEM) is employed for analyzing large deformations of the skin model. A thin plate simulates a 3D skin model with a finer mesh and takes the boundary conditions. This study aims to juxtapose experimental data with in vivo mechanical properties by employing Ogden’s coefficients to simulate the behavior of the skin model using the finite element method with an Analysis System (ANSYS). The obtained numerical model effectively illustrates the non-linear behavior of the skin. Furthermore, comparing three variations of the Ogden model, ranging from 1st order to 3rd order, elucidates the differential impact in various scenarios. In general, all of the results from experiments can show the mechanical behavior of the hyperelastic model. The numerical results show the utility of these parameters in human skin simulation in 3D elements (SOLID186) and illustrate an approximate bow wave shape and the occurrence of wrinkling in the test area, which is considered an artificial human skin model.