This study explores the solvothermal synthesis of ZnO particles, utilizing triethanolamine (TEA) and sodium hydroxide (NaOH) as key reagents, to identify the most effective protocol for the subsequent production of high-quality nanosized particles through microfluidics methods. Analytical techniques, including dynamic light scattering (DLS), UV-Vis absorption spectroscopy, and scanning electron microscopy (SEM), were employed to investigate the effects of variables such as reaction time, precursor composition, and concentration. The findings indicate that TEA significantly outperformed NaOH in facilitating the synthesis of ZnO particles, with the Zn-5TEA sample synthesized at 150 ℃ demonstrating the most favorable UV-Vis absorption characteristics, including a pronounced peak. Moreover, higher concentrations of TEA resulted in smaller, more uniform nanoparticles. Morphological analysis revealed that Zn-NaOH samples predominantly formed cylindrical particles, whereas Zn-TEA samples exhibited hexagonal morphologies, underscoring the influence of synthesis conditions on particle shape. In conclusion, TEA, particularly at a concentration of 5%, proved superior to NaOH in the synthesis of high-quality ZnO particles, making it especially suitable for producing nanoparticles.