Digital transformation is creating new digital spheres of experience and venues for everyday interaction. New cyberspaces are emerging that have the potential to fundamentally change the way we live and communicate. The conceptual understanding of spaces, places, and environments is changing. This has implications for understanding health-promoting settings. The questions arise whether the common understanding of settings and the setting approach of the World Health Organization is still appropriate today and what challenges and opportunities for health promotion and prevention arise with the expansion of settings to digital spaces, places, and environments.