This chapter outlines the potential of digital technology to advance public health research and inform evidence-based policies and practices. A substantial increase in research output in digital public health, mainly since about 2010, attests to the growing importance and dynamic of the field. Rather than discussing individual research methods or a specific research agenda, the chapter uses a concrete example to discuss relevant principles: a novel digital public health platform incorporating citizen science, participatory health research, and systems science concepts. The SMART framework is a platform to combine community-based participatory research, citizen science, and systems science, combining mobile phones and sensor technology with qualitative data collection. It is a starting point for a holistic human-centered digital public health research approach. Further overarching aspects illustrated in the chapter comprise Artificial Intelligence, advanced visualization and analytics, ethical issues, and data management. Digital public health research has to be conducted in interdisciplinary teams, and there is an increasing number of networks and centers that enhance these collaborations. The chapter stresses the need for continued investment in digital public health research and innovation to harness technology’s transformative potential.