In this chapter, we investigate the development and implementation of digital health technologies in public health using the perspective of digital entry points into the overall systems of health determinants. We use current case studies to illustrate how digital technologies can enter and shape the sphere of health and social interventions or—through their post-entry diffusion—lead to positive or adverse consequences. We present digital extensions of widely used socio-ecological models of health that illustrate entry points and interactions and outline strategies for how identified entry points on various levels can be used to develop strategies for wider dissemination of digital approaches for public health, e.g., through participatory research. Further applied examples focusing on co-created tools and interventions to address social media misinformation illustrate some of the analytic and developmental potentials of the perspectives outlined in this chapter.