The existing ankle rehabilitation system is vulnerable to complex parameter changes, which leads to high throughput rate of the system, so a table tennis player ankle rehabilitation system based on virtual reality and medical Internet of Things is proposed. In the hardware part, PCM3362 main controller, Gold driver, and EC motion control card are designed. Based on virtual reality and medical Internet of Things, the software generates the ankle rehabilitation control program for table tennis players, constructs the ankle rehabilitation model for table tennis players, and develops the ankle rehabilitation control process for table tennis players, thus realizing the ankle rehabilitation of table tennis players. The system test results show that the designed ankle rehabilitation system based on virtual reality and medical Internet of things has a low throughput rate and good rehabilitation training effect.