The technological era in which we live reflects the profound transformation that the world is undergoing and the constant need for organisations to adapt to remain competitive. This context brings together different technological scenarios that require a multidisciplinary and attentive approach on the part of organisational psychology, since the process of Knowledge ManagementKnowledge management goes hand in hand with Industry 4.0Industry 4.0 and Artificial IntelligenceArtificial intelligence. In the current chapter, entitled ‘Industry 4.0Industry 4.0: Knowledge ManagementKnowledge management with Artificial Intelligence?’ we propose to analyse the role of Knowledge ManagementKnowledge management in Industry 4.0 and interrogate the influence of Artificial IntelligenceArtificial intelligence on the Knowledge ManagementKnowledge management process. A literature review was carried out using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), as well as an analysis of the dataData collected in a case study, using interviews, focus groupFocus group and a questionnaire survey on Knowledge ManagementKnowledge management in Industry 4.0Industry 4.0. The era of Industry 4.0Industry 4.0 has specific characteristics, directly associated with the incorporation of information technologies into the production process and is seen as a new industrial reality with production models in which equipment, instruments, tools and processes of different kinds are connected and coexist almost autonomously (Junior, G. T., & Saltorato, P. (2018). Impactos da indústria 4.0 na organização do trabalho: uma revisão sistemática da literatura impacts of the industry 4.0 on work organization: a systematic review of the literature, 18(2), 743–769). Our interest was to problematise this technological environment in its connection to the phenomenon of Knowledge ManagementKnowledge management in an industrial environment.