Hand grip strength (GS) is reduced when fingers are excluded in pairs and triplets. The ratio is determined by the number of excluded fingers. The study's primary goal was to see how enslavement effects (EE) affected grip strength during multi-finger exclusions in primary and secondary hands. The study included 99 healthy male individuals ranging in age from 20 to 70 years (mean (SD), 31.78 (13.30)). Based on the finger configurations chosen, L (Little), R (Ring), M (Middle), I (Index), and T (Thumb) were eliminated in pairs: RL, IM, and IT, and a triplet: IMT utilizing finger braces. They were IMT, MRL, RL, and RLT, with the exclusions RL, TI, IMT, and IM. The mean GS of the IMT configuration was 17.59 kg, which was greater than the RLT, which was 14.06 kg since the IMT configuration includes the most and second most independent fingers, T and I, as well as the greatest contributing digit to GS, M. According to the study's findings, the EE has a considerable influence on the GS during multi-finger exclusions.