Despite the increasing automation of production systems in recent years, the human factor remains one of the key elements of companies’ competitiveness in this constantly changing environment. This transformation of the industrial world has led to a perpetual questioning of production methods, particularly regarding the inclusion of operators. The challenges associated with multi-manned assembly lines involve efficiently distributing work and tasks among multiple workers. The goal is to enhance productivity and effectiveness by considering the skills, assignments, and constraints of each worker to minimize workload imbalances and fully leverage the available human resource. The scope encompasses both single-criterion and multi-criteria optimization problems (MALBP), as well as exact and heuristic solution methods to address different objectives such as reducing line length and the number of workers. This article provides a concise overview of the literature on the current challenges related to the problem of balancing multi-manned, emphasizing worker assignment criteria for stations and proposing avenues for further research.