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In the first two parts of this monograph we have focused on group sequential and adaptive designs for a single hypothesis. However, in many clinical trials multiple study objectives are investigated, leading to multiple hypotheses of interest. Sometimes the wish is then to use the information available up to an interim analysis to adapt the hypotheses under investigation. We consider two examples to motivate the need for adaptive designs with multiple hypotheses. Other applications and case studies will be described and discussed in detail later in Chap. 12.

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Multiple Testing in Adaptive Designs

  • 章节

  • 发表日期：

    2025年

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  • Gernot Wassmer,
  • Werner Brannath

摘要

In the first two parts of this monograph we have focused on group sequential and adaptive designs for a single hypothesis. However, in many clinical trials multiple study objectives are investigated, leading to multiple hypotheses of interest. Sometimes the wish is then to use the information available up to an interim analysis to adapt the hypotheses under investigation. We consider two examples to motivate the need for adaptive designs with multiple hypotheses. Other applications and case studies will be described and discussed in detail later in Chap. 12.