The aim of this chapter is to provide a framework for clinical reasoning in the remote consultation setting, in order to encourage self-reflection on the cognitive process employed during the consultation. An overview of the literature on clinical reasoning is presented, emphasizing the special features of reasoning in primary care, which include: the low prevalence of disease and the duty to exclude serious diseases and not necessarily to arrive at a ‘diagnostic satiation’; the management of uncertainty; the attention to context and thus not only to clinical but also to non-clinical problems; and the longitudinal relationship with patients. Clinical reasoning is not limited to the consultation itself, and strategies outside the consultation as the ‘test of time’ can be implemented. The ideal steps of the process are presented, in order to reflect on the tools used and evaluate them. During the step of generating clinical hypotheses, we will stress the importance of listening quietly, but attentively, to the patient in order to gather more, albeit less detailed, information. During the step of verifying the hypotheses, we emphasize on the importance of arriving at a working diagnosis. During the step of contextualizing the working diagnosis, we focus attention on the importance of evaluating the uncertainty and of activating strategies to avoid errors; and, in the step of ‘plan-and-choose’, we discuss the importance of shared decision-making.