Lifestyle behavior depends on cultural and behavioral habits directly allied to health awareness, which may lead to a healthy life and society. Lifestyle behavior is in trouble cause of different health problems and economic and environmental challenges. All cities and megacities in developing countries contain huge slum areas with high population growth. As a result, they faced different vulnerability conditions and economic crises, which turned into bad hygienic practices that increased their health risk. Most slum neighborhoods are confronted with health shocks for a whole year and are forced to take a loan or mortgage loan and sell their household property to recover from health shocks. This chapter recognizes the key determinants accountable for such notorious problems, evaluates the perception variations among the slum neighborhoods regarding factors of health behaviors and risk, measures the effects of health-related behaviors and issues on physical and psychological health as well, and evaluates the effectiveness of existing measures to curb this problem. Geostatistical techniques with GIS mapping have been applied for the spatial distribution of these phenomena. The employed model would have been helpful to explore the significant factors in this concern.