This final chapter offers insightful career guidance to aspiring and incumbent academic deans. The information that it provides is particularly relevant given the dynamic environment of contemporary higher education and the many unprecedented challenges that it presents to an institution’s continued success and at times survival. You will benefit from approaching the topics synergistically and recognizing that collectively they provide mission-critical guidance as you prepare for a successful career as an academic dean. The chapter relates strategies that academic deans can utilize to ensure their continued agility, resilience, and success as well as that of the institutions and employees that they lead.