This chapter applies the anti-discriminatory approach to social work practice found in the resilience-enhancing stress model to a lesbian couple facing a midlife transition involving a critical health care event. It provides social workers with a family-centered methodology that addresses issues of diversity, equity, and inclusion. The processes of meaning-making, self-reflection, and ongoing identity formation are used to enhance resilient social functioning. A practice example describes the person–environment factors that influence the couple’s resilience as they resisted homophobia, heterosexism, ableism, and ageism and reconstructed their family narrative over time.