This chapter discusses the hybrid approach to tunneling using drill and blast and TBM in detail, answering why and when this hybrid method is used. The First Kaynarca-Kartal-Kadıköy Metro Line in Istanbul, with twin tunnels of 26.5 × 2 km, is given as an example. Almost 2/3 of this line is excavated with drill and blast; the rest is excavated with 2 EPB-TBM. The methodology, advantages, and results of using two different tunneling methods in this highly populated area of Istanbul are discussed. Another example of a hybrid tunneling project is the Kargı hydropower project in Turkey. The 7.8 km of the total length of 11.8 km of the tunnel is excavated with a double shield TBM of 9.84 m diameter, and 4 km of the tunnel from the inlet part is opened with NATM due to the challenging ground conditions faced by the TBM. The Bahçe-Nurdağ railway tunnel in Turkey consists of two parallel 9.75 km tunnels excavated by drill and blast and by 8 m diameter single shield TBM. Risk analysis showed that the first km of this tunnel was risky for TBM since the tunnel’s starting point was highly disturbed by the tectonic stresses created by the East Anatolian fault, and thereafter, this short length of the tunnel was opened by drill and blast. The final example is the Mount Macdonald tunnel, the longest railway tunnel of 14 km in Canada. The contractor for the East Tunnel of 8478 m used a 6.8 m diameter gripper-type TBM for the top heading. The bench was then excavated by drill and blast. The west tunnel of 6066 m was excavated by drill and blast with another contractor.