Fluoroscopy is a widely utilized imaging modality for diagnosis and interventional procedures. This chapter provides an overview of different fluoroscopy configurations, their related imaging techniques, patient safety concerns, and image quality concerns. Special attention is paid to patient safety, especially regarding radiation dose and the methods available to manage it. Following that, fluoroscopy quality control requirements are reviewed, with a discussion of relevant regulations and guidelines. A brief primer on the use of artificial intelligence (AI) tools in interventional radiology and cardiac catheterization is also included in the chapter. Finally, organizational and industry efforts to improve quality and safety in fluoroscopy are presented.