Based on the design experience of common anti-seepage types for the reservoir basin in conventional pumped storage power station projects, this paper comprehensively compares and analyzes the advantages and disadvantages of various single anti-seepage types and comprehensive anti-seepage types. In light of the characteristics of seawater pumped storage power station projects, it also explores the design schemes of anti-seepage types for the reservoir basin in the seawater environment. Two design schemes are put forward: (1) For the reservoir bottom, the combined anti-seepage type of geomembrane and clay is adopted, and for the bank slope, the anti-seepage type combining the reinforced concrete panel and protective coating is used. (2) The anti-seepage type of integrated geomembrane for the reservoir bottom and bank slope is adopted. The discussion in this paper on the design schemes of anti-seepage types for the reservoir basin of seawater pumped storage power stations can provide suggestions for the engineering design of future seawater pumped storage power stations.