This chapter explores the role of positive psychology interventions (PPIs) in enhancing the psychological well-being of university students in Africa. It introduces the concept of positive psychology and its significance in addressing mental health challenges within higher education. The chapter delves into positive psychology interventions (PPIs), with a particular focus on their application and outcomes in university settings. Using the PERMA framework, the chapter analyzes various interventions employed across African universities. The existing literature on the subject is reviewed, highlighting successes, challenges, and contextual adaptations of PPIs. Finally, it discusses the implications for clinicians and practitioners working with higher education students, offering actionable recommendations for improving student well-being.