Piezoelectric polymers are highly valued for their enormous potential for biomedical engineering applications. Among them, non-biodegradable poly(vinylidene fluoride) (PVDF) is well-known for its high piezoelectric coefficient, which is very suitable for sensor and energy harvesting applications. Biodegradable piezoelectric polymers, such as poly(L-lactide) (PLLA), polyhydroxyalkanoates (PHAs) or natural polymers (collagen, chitosan or cellulose nanofibers), show enormous potential for biomedical applications like tissue engineering, as they integrate seamlessly with native tissues. These characteristics make piezoelectric biodegradable polymers ideal for implantable systems, since they avoid surgical removal and reduce inflammation associated to the long-term exposure to external materials. Nevertheless, the mechanical properties, bioresorption rate, thermal stability, piezoelectric response and other functional properties may need to be tailored, so as they can match the requirements for the specific biomedical application. The development of piezoelectric polymer blends aims to overcome these limitations by combining the advantages of various piezoelectric polymers. This chapter emphasizes the promising potential and critical role of piezoelectric polymer blends in advancing biomedical technologies, enabling innovative applications in tissue engineering, wearable electronics and energy harvesting devices.