This chapter explores tourism as a place and knowledge-based activity, emphasizing its inherent characteristics of spatiality, co-terminality and temporality. Tourism is deeply embedded in the uniqueness of places, requiring the integration of cultural and natural resources into tourism products while considering long-term sustainability, taking into account the challenges of their economic valuation. The chapter highlights how contemporary tourism services can benefit from direct digital interactions between consumers and providers, fostering potential co-creation and adaptation processes. The digitalization of tourism has expanded these interactions beyond the physical journey, with ICT and Big Data transforming the industry into a knowledge-intensive sector. Case studies from Amsterdam, Leipzig and Shiretoko illustrate how digital tools and information flows enhance destination management, visitor satisfaction and economic integration. Ultimately, the chapter underscores tourism’s role in regional development, specialization and innovation, justifying the adoption of place-based strategies to harness its economic and socio-cultural potential while mitigating negative externalities.