This chapter examines the transformative role of e-commerce in destination marketing, sustainable tourism practices, and the future of the tourism industry. E-commerce platforms enhance global visibility and enable precise targeting through data analytics, improving promotional efforts and shaping consumer behaviour. They facilitate partnerships with influencers and local businesses, supporting economies while optimizing visitor experiences. Additionally, e-commerce promotes sustainable practices by showcasing eco-friendly options and encouraging responsible travel. Despite challenges like data management, resource constraints, and cybersecurity risks, strategic investments and adherence to security protocols are crucial. The integration of artificial intelligence (AI), personalization, and voice search technology is also explored, highlighting their potential to reshape customer experiences and operational efficiencies. This study emphasizes the critical role of e-commerce in fostering sustainable growth and resilience in the evolving tourism landscape.