Catalysis has played a crucial role in the advancement of human society by facilitating reactions that would otherwise be kinetically sluggish or thermodynamically unfavorable. Considerable efforts have been dedicated to achieving a comprehensive understanding of the fundamental mechanisms underlying catalysis, leading to the development of novel catalytic strategies with exceptional performance. Contact-electro-catalysis (CEC) represents an emerging field that employs contact-electrification-driven electron transfer to facilitate redox reactions. Due to the widespread nature of the contact-electrification effect, nearly all organic and inorganic materials can potentially serve as CEC catalysts, with the energy source being universally applicable but often wasted mechanical energy. This paradigm-shifting technology unveils promising avenues for the devise of novel catalysts and catalytic processes. This chapter provides a comprehensive overview of the theoretical foundation of CEC, strategies for improving CEC, and the unique advantages of CEC. Additionally, a roadmap for future research and development of CEC has been proposed. We aspire for this chapter to motivate in-depth investigations within the chemistry and materials community to further investigate CEC, a catalytic process in nature.