With the rapid progression of society and the continuous advancement of industrialization, catalysis has become an indispensable tool in manufacturing, energy conversion and storage, resource recycling, and environmental management. Over the past few decades, electrocatalysis and photocatalysis have been widely recognized as the most promising approaches to support sustainable development. In recent years, emerging catalytic methods such as contact-electro-catalysis (CEC) have also garnered considerable attention and research efforts. CEC is based on the interdisciplinary mechanism of physics and chemistry, and specifically, realized through interfacial electron transfer during the mechano-driven solid–liquid (or liquid–liquid, etc.) contact electrification process, which differs from conventional catalytic principles in terms of both electron and energy sources. This endows CEC with the characteristics of being environmentally friendly, low-energy-consuming, and offering a wider range of catalyst options. Here, in this chapter, we will review the potential applications of CEC that have been proposed thus far, including water treatment, carbon dioxide capture, nitrogen fixation, hydrogen peroxide generation, recycling of lithium-ion cathode materials, and cancer therapy.